Ogólnoustrojowe dostarczanie ukierunkowane nanoterapii odwraca tętniaki

Ogólnoustrojowe dostarczanie ukierunkowane nanoterapii odwraca tętniaki aorty brzusznej wywołane przez angiotensynę II u myszy

Choroba tętniaka aorty brzusznej (AAA) powoduje rozszerzenie aorty, co prowadzi do pęknięcia aorty i śmierci, jeśli nie jest wcześnie leczona. Jest to 14. najczęstsza przyczyna zgonów w Stanach Zjednoczonych i 10. najczęstsza przyczyna zgonów mężczyzn w wieku powyżej 55 lat, dotykająca tysiące pacjentów.

Pomimo rozpowszechnienia AAA, nie ma bezpiecznych i skutecznych farmakoterapii dla pacjentów. Uszkodzenie elastycznej blaszki ściany tętniaka jest stałą cechą AAA, co czyni go idealnym celem do dostarczania leków do miejsca tętniaka. W tym badaniu  połączyliśmy  nanocząstki z przeciwciałem elastyny,   które celuje tylko w zdegradowaną elastynę, oszczędzając jednocześnie zdrową elastynę.

Po wywołaniu tętniaka przez 4-tygodniową infuzję angiotensyny II (Ang II), dwa dwutygodniowe dożylne wstrzyknięcia nanocząsteczek obłożonych pentagalloiloglukozą (PGG)  sprzężonych  z przeciwciałem elastyny   dostarczyły lek do miejsca tętniaka. Pokazujemy, że ukierunkowane dostarczenie PGG może odwrócić rozszerzenie aorty, złagodzić stan zapalny, przywrócić elastyczną blaszkę i poprawić właściwości mechaniczne aorty w miejscu AAA. Dlatego prosta terapia dożylna nanocząsteczek obciążonych PGG może być skuteczną opcją leczenia tętniaków we wczesnym i średnim stadium w celu odwrócenia progresji choroby i przywrócenia aorty do normalnej homeostazy.

Błąd połączenia.

Glikoinżynieria przeciwciało i przygotowanie koniugatu homogenicznego przeciwciało-lek

 

Koniugaty przeciwciało- lek (ADC) to klasa biofarmaceutyków, w których środki cytotoksyczne są  sprzężone  z przeciwciałami  monoklonalnymi  (mAb), umożliwiając ukierunkowane dostarczanie leków. Obecne ADC heterogeniczne ( sprzężone  w losowych pozycjach zmiennych), cierpiała od kwestii stabilności, powtarzalności, skuteczność, itp Ostatnie postępy doprowadziły do opracowania preparatów jednorodnych ADC przez miejscowo specyficzną koniugacji, co pozwala na sterowanie lek To- przeciwciała  stosunek . Podejścia te zwiększyły okno terapeutyczne, skuteczność i powtarzalność serii preparatów ADC. Przeciwciała  niosą parę heterogennych N-glikanów w regionach Fc, które są krytyczne dla  przeciwciała funkcjonować.

Koniugację leków za pomocą glikoinżynierii osiągnięto różnymi podejściami, w tym z użyciem endo-β-N-acetyloglukozaminidazy (ENGazy) i mutantów transferazy monosacharylowej. W tym artykule podsumowujemy różne podejścia  inżynierii glikemicznej do koniugacji przeciwciało -lek i omawiamy ich zalety w opracowywaniu homogenicznych ADC nowej generacji.

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Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled

AP-301-F 1 mg Ask for price

Donkey anti Goat IgG (H + L) (Alexa Fluor 594)

43R-ID005AF 500 ug
EUR 338
Description: Donkey anti Goat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey anti Rat IgG (H + L) (Alexa Fluor 594)

43R-ID022AF 500 ug
EUR 364
Description: Donkey anti Rat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey anti Rat IgG (H + L) (Alexa Fluor 594)

43R-ID047AF 500 ug
EUR 462
Description: Donkey anti Rat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey anti Chicken IgY (H + L) (Alexa Fluor 594)

43R-ID056AF 500 ug
EUR 343
Description: Donkey anti Chicken IgY secondary antibody (H + L) (Alexa Fluor 594)

Rabbit anti Chicken IgY (H + L) (Alexa Fluor 594)

43R-IR016AF 1 mg
EUR 281
Description: Rabbit anti Chicken IgY (H + L) secondary antibody (Alexa Fluor 594)

Anti-Alpha v Beta Integrin antibody

STJ16100153 1 mL
EUR 720

Goat Anti-Mouse IgG(H+L) Alexa Fluor 594–conjugated

S0005 200ul
EUR 376

Goat Anti-Rabbit IgG(H+L) Alexa Fluor 594–conjugated

S0006 200ul
EUR 376

Rabbit Anti-Rat IgG (H+L)-Alexa 594 Fluor conjugate (adsorbed with human IgG)

50337 0.5 ml
EUR 225

Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody

CABT-49626MH 0.1 mg
EUR 1375

Integrin Alpha V Beta 5 (ITGAV/ITGB5) Antibody

abx411439-01mg 0.1 mg
EUR 913

anti-Integrin alpha V

YF-PA12786 50 ul
EUR 363
Description: Mouse polyclonal to Integrin alpha V

anti-Integrin alpha V

YF-PA12787 50 ug
EUR 363
Description: Mouse polyclonal to Integrin alpha V

anti-Integrin alpha V

YF-PA12788 100 ug
EUR 403
Description: Rabbit polyclonal to Integrin alpha V

Donkey Anti-Goat IgG (H+L), Alexa Fluor® 594 Conjugated

Ab8011-001 1mg
EUR 334

Donkey anti Goat IgG (H + L) (Fab 2) (Alexa Fluor 594)

43R-ID012AF 300 ug
EUR 410
Description: Donkey anti Goat IgG (H + L) secondary antibody (Fab'2) (Alexa Fluor 594)

AF594-streptavidin conjugate [Streptavidin, Alexa Fluor™ 594 Conjugate]

16892 1 mg
EUR 176

AF594 Phalloidin [equivalent to Alexa Fluor® 594 phalloidin]

23158 300 Tests
EUR 306

Anti-RPSA Alexa Fluor® 488

A4-829-C100 0.1 mg
EUR 310

Anti-CD40 antibody (Alexa-fluor 488)

STJ170000 100 µg
EUR 393
Description: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin

Anti-LAMP3 antibody (Alexa-fluor 488)

STJ170004 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-LAMP3 antibody (Alexa-fluor 546)

STJ170005 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-LAMP3 antibody (Alexa-fluor 647)

STJ170006 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-IL3RA antibody (Alexa-fluor 488)

STJ170009 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-IL3RA antibody (Alexa-fluor 546)

STJ170010 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-IL3RA antibody (Alexa-fluor 647)

STJ170011 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-CD207 antibody (Alexa-fluor 488)

STJ170014 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-CD207 antibody (Alexa-fluor 546)

STJ170015 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-CD207 antibody (Alexa-fluor 647)

STJ170016 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-IL7R antibody (Alexa-fluor 488)

STJ170020 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Anti-IL7R antibody (Alexa-fluor 546)

STJ170021 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Anti-IL7R antibody (Alexa-fluor 647)

STJ170022 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Integrin alpha V beta 6 antibody

10R-11286 100 ug
EUR 814
Description: Mouse Monoclonal Integrin alpha V beta 6 antibody

Alpha Fluor™ 594 C5 Maleimide

1891 1 mg
EUR 219

Endoglin/CD105 Alexa Fluor

FC15024 100 Tests
EUR 448

Streptavidin-Alexa594 (Alexas fluor 594) conjugate

SV-A594-100 100 tests
EUR 225

anti-Integrin beta 5

YF-PA24023 50 ul
EUR 334
Description: Mouse polyclonal to Integrin beta 5

anti-Integrin beta 5

YF-PA12792 100 ug
EUR 403
Description: Rabbit polyclonal to Integrin beta 5

Anti-Hu CD16 Alexa Fluor® 488

A4-646-T100 100 tests
EUR 269

Goat anti Mouse IgG1 (Alexa Fluor 488)

43R-1649 500 ug
EUR 570
Description: Goat anti Mouse IgG1 secondary antibody (Alexa Fluor 488)

Anti-Integrin alpha V/ITGAV Antibody

PA1405 100ug/vial
EUR 334

SAM FCM (Alexa Fluor 647)

abx098902-100tests 100 tests
EUR 1233

SAM FCM (Alexa Fluor 488)

abx098904-60tests 60 tests
EUR 1358

EGFR antibody (Alexa Fluor 488)

61R-E109BAF 125 ug
EUR 706
Description: Mouse monoclonal EGFR antibody (Alexa Fluor 488)

Anti-Integrin beta 5 antibody

STJ70659 100 µg
EUR 359

anti- Integrin beta-5 antibody

FNab04352 100µg
EUR 505.25
Description: Antibody raised against Integrin beta-5

Anti-Integrin beta 5 (1D8)

YF-MA13874 100 ug
EUR 363
Description: Mouse monoclonal to Integrin beta 5

Anti-Integrin beta-5 antibody

PAab04352 100 ug
EUR 355

Alpha Fluor™ 532 acid [equivalent to Alexa Fluor™ 532 acid]

1795 10 mg
EUR 393

Human CellExp™ Integrin alpha V beta 5 Heterodimer, Human recombinant

P1121-10 Ask for price

Human CellExp™ Integrin alpha V beta 5 Heterodimer, Human recombinant

P1121-50 Ask for price

Integrin alpha V Antibody

48926-100ul 100ul
EUR 333

Integrin alpha V Antibody

48926-50ul 50ul
EUR 239

Integrin alpha V Antibody

AF5152 200ul
EUR 304
Description: Integrin αV Antibody detects endogenous levels of total Integrin αV.

Anti-integrin alpha(v)beta(3) (Etaracizumab)-SMCC-DM1 ADC

ADC-W-1496 1mg Ask for price
Description: This ADC product is comprised of an anti-integrin alpha(v)beta(3) monoclonal antibody conjugated via a SMCC linker to DM1

Anti-integrin alpha(v)beta(3) (Etaracizumab)-SPDB-DM4 ADC

ADC-W-1497 1mg Ask for price
Description: This ADC product is comprised of an anti-integrin alpha(v)beta(3) monoclonal antibody conjugated via a SPDB linker to DM4

Anti-integrin alpha(v)beta(3) (Etaracizumab)-MC-MMAF ADC

ADC-W-1498 1mg Ask for price
Description: This ADC product is comprised of an anti-integrin alpha(v)beta(3) monoclonal antibody conjugated via a MC linker to MMAF

anti- Integrin alpha-5 antibody

FNab04347 100µg
EUR 548.75
Description: Antibody raised against Integrin alpha-5

Anti-Integrin alpha-5 antibody

PAab04347 100 ug
EUR 386

Recombinant (E.Coli) Human Thyrostimulin Beta

RP-594 10 ug
EUR 286

Integrin Beta 3/Alpha V (ITGB3/ITGAV) Antibody

abx415500-02mg 0.2 mg
EUR 565

Integrin Beta 3/Alpha V (ITGB3/ITGAV) Antibody

abx415501-01mg 0.1 mg
EUR 439

Anti-Integrin alpha V Rabbit Monoclonal Antibody

M01561 100ug/vial
EUR 397
Description: Anti-Integrin alpha V Rabbit Monoclonal Antibody tested for IP, IF, IHC, ICC, WB in Human, Mouse, Rat

Anti-Integrin alpha V Rabbit Monoclonal Antibody

M01561-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Integrin alpha V Antibody. Validated in WB and tested in Human, Mouse, Rat.

Rabbit Anti-Rat IgG (H+L)-Alexa 488 Fluor conjugate (adsorbed with human IgG)

50336 0.5 ml
EUR 225

Integrin Alpha V (ITGaV) Antibody

20-abx172960
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug

Integrin Alpha V (ITGaV) Antibody

20-abx129744
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Integrin Alpha V (ITGaV) Antibody

20-abx128150
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Integrin Alpha V (ITGAV) Antibody

abx117202-100ug 100 ug
EUR 467

Integrin Alpha V (ITGAV) Antibody

20-abx001703
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Integrin alpha V Rabbit mAb

A19071-100ul 100 ul
EUR 410

Integrin alpha V Rabbit mAb

A19071-200ul 200 ul
EUR 571

Integrin alpha V Rabbit mAb

A19071-20ul 20 ul
EUR 221

Integrin alpha V Rabbit mAb

A19071-50ul 50 ul
EUR 287

Integrin Alpha V (ITGAV) Antibody

20-abx323298
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Integrin Alpha V (ITGAV) Antibody

20-abx338429
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Integrin Alpha V (ITGAV) Antibody

20-abx325867
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Integrin alpha V Conjugated Antibody

C48926 100ul
EUR 397

Human Integrin alpha-V (ITGAV)

1-CSB-YP011877HU
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Integrin alpha-V(ITGAV),partial expressed in Yeast

Recombinant Integrin Alpha V (ITGaV)

4-RPB282Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Integrin Alpha V expressed in: E.coli

Recombinant Integrin Alpha V (ITGaV)

4-RPB282Mu01
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Integrin Alpha V expressed in: E.coli

Integrin alpha V Blocking Peptide

AF5152-BP 1mg
EUR 195

Anti-Hu CD72 Alexa Fluor® 488

A4-310-T100 100 tests
EUR 269

Anti-Bov CD9 Alexa Fluor® 488

A4-354-C100 0.1 mg
EUR 269

Anti-Hu CD30 Alexa Fluor® 700

A7-455-T100 100 tests
EUR 269

Anti-Hu CD94 Alexa Fluor® 700

A7-727-T100 100 tests
EUR 269

Anti-Hu CD56 Alexa Fluor® 700

A7-789-T100 100 tests
EUR 269

Donkey anti Goat IgG (H + L) (Alexa Fluor 647)

43R-ID028AF 500 ug
EUR 430
Description: Donkey anti Goat IgG (H + L) secondary antibody (Alexa Fluor 647)

Donkey anti Chicken IgY (H + L) (Alexa Fluor 647)

43R-ID060AF 300 ug
EUR 425
Description: Donkey anti Chicken IgY (H + L) (Fab'2) (Alexa Fluor 647)

Anti-Integrin alpha 5/ITGA5 Antibody

PB9254 100ug/vial
EUR 294

Anti-Integrin alpha 5/ITGA5 Antibody

A01911 100ug/vial
EUR 334

Human CellExp? Integrin alpha V beta 8, Human recombinant

P1122-10
EUR 164

Human CellExp? Integrin alpha V beta 8, Human recombinant

P1122-50
EUR 615

Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

A1092-200
EUR 729

Integrin beta-5 Antibody

AF5327 200ul
EUR 304
Description: Integrin β5 Antibody detects endogenous levels of total Integrin β5.

Integrin beta-5 Antibody

AF0185 200ul
EUR 304
Description: Integrin beta-5 antibody detects endogenous levels of total Integrin beta-5.

Integrin beta- 5 Antibody

ABF0185 100 ug
EUR 438

Azotogenaza w Frankia z guzków korzeni Alnus incana (L.) Moench: immunolokalizacja białek Fe i MoFe podczas różnicowania pęcherzyków

 

Lokalizację azotazy badano w guzkach korzeni Alnus incana (L.) Moench w symbiozie z lokalnym źródłem Frankia. Guzki utrwalono w glutaraldehydzie i zatopiono w Epon lub LR White. Ultracienkie skrawki badano za pomocą TEM po inkubacji z surowicami odpornościowymi przeciwko azotazie i przeciwciałom  wtórnym  sprzężonym ze złotem . Zastosowano surowice odpornościowe przeciwko reduktazie dinitrogenazy (białko Fe) z Rhodospirillum rubrum i dinitrogenazę (białko MoFe) z Azotobacter vinelandii. Gęstość znacznika Immunogold w strzępkach i zarodnikach Frankii była niska i podobna do gęstości tkanki roślinnej.

Bardzo młode pęcherzyki bez przegród wykazywały gęstość znacznika białka Fe podobną do gęstości strzępek, podczas gdy młode pęcherzyki z kilkoma, zwykle nieprzekształcającymi się przegrodami, miały znaczną, ale wciąż niską gęstość znacznika. Dojrzałe pęcherzyki, silnie kompartmentalizowane z powodu przegród poprzecznych , zawierały statystycznie istotnie więcej znacznika białka Fe niż wszystkie inne typy komórek. Stare, degenerujące się pęcherzyki zawsze zawierały azotazę, około połowę mniej niż pęcherzyki dojrzałe, ale często więcej niż pęcherzyki młode. Podobnie, znacznik MoFe nie został wykryty w strzępkach, pojawił się u młodych, ale był największy w dojrzałych pęcherzykach. Widać, że różnicowanie pęcherzyków osiąga pewien etap rozwoju przed rozpoczęciem syntezy azotazy.

 

Optyczna spektroskopia emisyjna w plazmie sprzężonej indukcyjnie jako narzędzie oceny testów bocznego

 

Testy przepływu bocznego (LFA) to immunochromatograficzne urządzenia w miejscu opieki, które mają duży wpływ na diagnostykę choroby dzięki szybkiemu, niedrogiem i łatwemu w użyciu współczynnikowi kształtu. Chociaż LFA odniosły sukces jako narzędzia do rozmieszczania w terenie, mają stosunkowo niski restrict wykrywalności w porównaniu z bardziej złożonymi metodami. Co więcej, większość optymalizacji projektowania i produkcji jest osiągana poprzez czasochłonną i zasobochłonną optymalizację siłową. Pomimo zwiększonego zainteresowania produkcją LFA, potrzebne są bardziej ilościowe narzędzia do badania obecnych protokołów produkcyjnych, a tym samym do dalszej optymalizacji i usprawnienia rozwoju tych urządzeń.

W tej pracy skupiamy się na krytycznym składniku LFA, złocie koloidalnym  sprzężonym  z przeciwciałem detekcyjnym  , jednym z najczęściej stosowanych elementów reporterowych. W badaniu tym wykorzystano optyczną spektroskopię emisyjną ze sprzężeniem indukcyjnym (ICP-OES) w połączeniu z czytnikiem przepływu bocznego do ilościowej analizy dystrybucji złota koloidalnego na liniach testu odczytu i kontrolnych, a także resztkowego złota na wkładce koniugatu i innych przepływach przez regiony. Naszym celem jest bardziej rygorystyczne zrozumienie obecnych projektów LFA, a także ilościowe zrozumienie niedociągnięć charakterystyk operacyjnych w celu przyszłej poprawy. Według naszej wiedzy jest to pierwszy przypadek, kiedy ICP-OES został użyty do badania początkowej dystrybucji złota koloidalnego naniewykorzystany LFA i jego redystrybucja po wykonaniu testu. Używając trzech różnych marek dostępnych na rynku LFA przeciw malarii, zmierzono zawartość złota w każdej sekcji LFA przy różnych testowych stężeniach pasożyta.

Zgodnie z oczekiwaniami całkowita masa złota pozostała niezmieniona po zastosowaniu LFA; jednakże całkowita masa początkowego złota i jego redystrybucja różniły się między producentami. Co ważne, te komercyjne projekty LFA mają również pewne nieodłączne nieefektywności ; na przykład tylko 30% całkowitego złota zdeponowanego na LFA marki A wiąże się z liniami testowymi i kontrolnymi, czyli częściami testu zawierającymi sygnał, który można zinterpretować. Korzystając z informacji zebranych za pomocą tej metody, przyszłe urządzenia mogą być bardziej celowo projektowane, aby skupić się na poprawie wydajności wiązania, co skutkuje obniżeniem kosztów, poprawą granic wykrywalności oraz mniejszą zmiennością między testami i producentami.

Wpływ surowicy na elektrochemiczną detekcję testów biologicznych posiadających etykiety nanocząstek Ag

 

Zbadano wpływ surowicy na elektrochemiczną detekcję testów biologicznych posiadających znaczniki detekcji nanocząstek srebra (AgNP). Zbadano zarówno take a look at modelowy , jak i take a look at biologiczny kanapkowy specyficzny dla antygenu dla markera niewydolności serca NT-proBNP. W obu przypadkach znaczniki AgNP były  sprzężone  z przeciwciałem do wykrywania  . Detekcję elektrochemiczną przeprowadzono metodą wymiany galwanicznej / anodowej woltamperometrii strippingowej, w której Au 3+  wymienia się ze znacznikami AgNP . Testy przeprowadzono przy użyciu papierowej platformy elektrodowej.

Testy biologiczne wystawiano na działanie różnych warunków surowicy przed i podczas wykrywania. W tym artykule opisano trzy ważne wyniki. Po pierwsze, testy specyficzne dla modelu i antygenu można było utworzyć w nierozcieńczonej surowicy bez wykrywalnych zakłóceń ze strony składników surowicy. Po drugie, aby osiągnąć maksymalny możliwy sygnał elektrochemiczny, najwyższy procent surowicy, który może pozostać w buforze testowym podczas wykrywania elektrochemicznego, wynosi 0,25%, gdy nie przeprowadza się płukania. Wyniki testu stają się niedokładne, gdy obecne jest 0,50% lub więcej surowicy . Po trzecie, czynniki hamujące wymianę galwaniczną w surowicy prawdopodobnie dotyczą powierzchniowej adsorpcji biomolekuł na znacznikach AgNP, chelatacji Au 3+ według składników surowicy lub obu. Przedstawione tutaj wyniki dostarczają ogólnych wskazówek dotyczących stosowania metalowych znaczników NP w testach elektrochemicznych w płynach biologicznych.

Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled

AP-301-F 1 mg Ask for price

Donkey anti Goat IgG (H + L) (Alexa Fluor 594)

43R-ID005AF 500 ug
EUR 338
Description: Donkey anti Goat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey anti Rat IgG (H + L) (Alexa Fluor 594)

43R-ID022AF 500 ug
EUR 364
Description: Donkey anti Rat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey anti Rat IgG (H + L) (Alexa Fluor 594)

43R-ID047AF 500 ug
EUR 462
Description: Donkey anti Rat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey anti Chicken IgY (H + L) (Alexa Fluor 594)

43R-ID056AF 500 ug
EUR 343
Description: Donkey anti Chicken IgY secondary antibody (H + L) (Alexa Fluor 594)

Rabbit anti Chicken IgY (H + L) (Alexa Fluor 594)

43R-IR016AF 1 mg
EUR 281
Description: Rabbit anti Chicken IgY (H + L) secondary antibody (Alexa Fluor 594)

Anti-Alpha v Beta Integrin antibody

STJ16100153 1 mL
EUR 720

Goat Anti-Mouse IgG(H+L) Alexa Fluor 594–conjugated

S0005 200ul
EUR 376

Goat Anti-Rabbit IgG(H+L) Alexa Fluor 594–conjugated

S0006 200ul
EUR 376

Rabbit Anti-Rat IgG (H+L)-Alexa 594 Fluor conjugate (adsorbed with human IgG)

50337 0.5 ml
EUR 225

Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody

CABT-49626MH 0.1 mg
EUR 1375

Integrin Alpha V Beta 5 (ITGAV/ITGB5) Antibody

abx411439-01mg 0.1 mg
EUR 913

anti-Integrin alpha V

YF-PA12786 50 ul
EUR 363
Description: Mouse polyclonal to Integrin alpha V

anti-Integrin alpha V

YF-PA12787 50 ug
EUR 363
Description: Mouse polyclonal to Integrin alpha V

anti-Integrin alpha V

YF-PA12788 100 ug
EUR 403
Description: Rabbit polyclonal to Integrin alpha V

Donkey Anti-Goat IgG (H+L), Alexa Fluor® 594 Conjugated

Ab8011-001 1mg
EUR 334

Donkey anti Goat IgG (H + L) (Fab 2) (Alexa Fluor 594)

43R-ID012AF 300 ug
EUR 410
Description: Donkey anti Goat IgG (H + L) secondary antibody (Fab'2) (Alexa Fluor 594)

AF594-streptavidin conjugate [Streptavidin, Alexa Fluor™ 594 Conjugate]

16892 1 mg
EUR 176

AF594 Phalloidin [equivalent to Alexa Fluor® 594 phalloidin]

23158 300 Tests
EUR 306

Anti-RPSA Alexa Fluor® 488

A4-829-C100 0.1 mg
EUR 310

Anti-CD40 antibody (Alexa-fluor 488)

STJ170000 100 µg
EUR 393
Description: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin

Anti-LAMP3 antibody (Alexa-fluor 488)

STJ170004 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-LAMP3 antibody (Alexa-fluor 546)

STJ170005 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-LAMP3 antibody (Alexa-fluor 647)

STJ170006 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-IL3RA antibody (Alexa-fluor 488)

STJ170009 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-IL3RA antibody (Alexa-fluor 546)

STJ170010 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-IL3RA antibody (Alexa-fluor 647)

STJ170011 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-CD207 antibody (Alexa-fluor 488)

STJ170014 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-CD207 antibody (Alexa-fluor 546)

STJ170015 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-CD207 antibody (Alexa-fluor 647)

STJ170016 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-IL7R antibody (Alexa-fluor 488)

STJ170020 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Anti-IL7R antibody (Alexa-fluor 546)

STJ170021 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Anti-IL7R antibody (Alexa-fluor 647)

STJ170022 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Integrin alpha V beta 6 antibody

10R-11286 100 ug
EUR 814
Description: Mouse Monoclonal Integrin alpha V beta 6 antibody

Alpha Fluor™ 594 C5 Maleimide

1891 1 mg
EUR 219

Endoglin/CD105 Alexa Fluor

FC15024 100 Tests
EUR 448

Streptavidin-Alexa594 (Alexas fluor 594) conjugate

SV-A594-100 100 tests
EUR 225

anti-Integrin beta 5

YF-PA24023 50 ul
EUR 334
Description: Mouse polyclonal to Integrin beta 5

anti-Integrin beta 5

YF-PA12792 100 ug
EUR 403
Description: Rabbit polyclonal to Integrin beta 5

Anti-Hu CD16 Alexa Fluor® 488

A4-646-T100 100 tests
EUR 269

Goat anti Mouse IgG1 (Alexa Fluor 488)

43R-1649 500 ug
EUR 570
Description: Goat anti Mouse IgG1 secondary antibody (Alexa Fluor 488)

Anti-Integrin alpha V/ITGAV Antibody

PA1405 100ug/vial
EUR 334

SAM FCM (Alexa Fluor 647)

abx098902-100tests 100 tests
EUR 1233

SAM FCM (Alexa Fluor 488)

abx098904-60tests 60 tests
EUR 1358

EGFR antibody (Alexa Fluor 488)

61R-E109BAF 125 ug
EUR 706
Description: Mouse monoclonal EGFR antibody (Alexa Fluor 488)

Anti-Integrin beta 5 antibody

STJ70659 100 µg
EUR 359

anti- Integrin beta-5 antibody

FNab04352 100µg
EUR 505.25
Description: Antibody raised against Integrin beta-5

Anti-Integrin beta 5 (1D8)

YF-MA13874 100 ug
EUR 363
Description: Mouse monoclonal to Integrin beta 5

Anti-Integrin beta-5 antibody

PAab04352 100 ug
EUR 355

Alpha Fluor™ 532 acid [equivalent to Alexa Fluor™ 532 acid]

1795 10 mg
EUR 393

Human CellExp™ Integrin alpha V beta 5 Heterodimer, Human recombinant

P1121-10 Ask for price

Human CellExp™ Integrin alpha V beta 5 Heterodimer, Human recombinant

P1121-50 Ask for price

Integrin alpha V Antibody

48926-100ul 100ul
EUR 333

Integrin alpha V Antibody

48926-50ul 50ul
EUR 239

Integrin alpha V Antibody

AF5152 200ul
EUR 304
Description: Integrin αV Antibody detects endogenous levels of total Integrin αV.

Anti-integrin alpha(v)beta(3) (Etaracizumab)-SMCC-DM1 ADC

ADC-W-1496 1mg Ask for price
Description: This ADC product is comprised of an anti-integrin alpha(v)beta(3) monoclonal antibody conjugated via a SMCC linker to DM1

Anti-integrin alpha(v)beta(3) (Etaracizumab)-SPDB-DM4 ADC

ADC-W-1497 1mg Ask for price
Description: This ADC product is comprised of an anti-integrin alpha(v)beta(3) monoclonal antibody conjugated via a SPDB linker to DM4

Anti-integrin alpha(v)beta(3) (Etaracizumab)-MC-MMAF ADC

ADC-W-1498 1mg Ask for price
Description: This ADC product is comprised of an anti-integrin alpha(v)beta(3) monoclonal antibody conjugated via a MC linker to MMAF

anti- Integrin alpha-5 antibody

FNab04347 100µg
EUR 548.75
Description: Antibody raised against Integrin alpha-5

Anti-Integrin alpha-5 antibody

PAab04347 100 ug
EUR 386

Recombinant (E.Coli) Human Thyrostimulin Beta

RP-594 10 ug
EUR 286

Integrin Beta 3/Alpha V (ITGB3/ITGAV) Antibody

abx415500-02mg 0.2 mg
EUR 565

Integrin Beta 3/Alpha V (ITGB3/ITGAV) Antibody

abx415501-01mg 0.1 mg
EUR 439

Anti-Integrin alpha V Rabbit Monoclonal Antibody

M01561 100ug/vial
EUR 397
Description: Anti-Integrin alpha V Rabbit Monoclonal Antibody tested for IP, IF, IHC, ICC, WB in Human, Mouse, Rat

Anti-Integrin alpha V Rabbit Monoclonal Antibody

M01561-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Integrin alpha V Antibody. Validated in WB and tested in Human, Mouse, Rat.

Rabbit Anti-Rat IgG (H+L)-Alexa 488 Fluor conjugate (adsorbed with human IgG)

50336 0.5 ml
EUR 225

Integrin Alpha V (ITGaV) Antibody

20-abx172960
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug

Integrin Alpha V (ITGaV) Antibody

20-abx129744
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Integrin Alpha V (ITGaV) Antibody

20-abx128150
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Integrin Alpha V (ITGAV) Antibody

abx117202-100ug 100 ug
EUR 467

Integrin Alpha V (ITGAV) Antibody

20-abx001703
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Integrin alpha V Rabbit mAb

A19071-100ul 100 ul
EUR 410

Integrin alpha V Rabbit mAb

A19071-200ul 200 ul
EUR 571

Integrin alpha V Rabbit mAb

A19071-20ul 20 ul
EUR 221

Integrin alpha V Rabbit mAb

A19071-50ul 50 ul
EUR 287

Integrin Alpha V (ITGAV) Antibody

20-abx323298
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Integrin Alpha V (ITGAV) Antibody

20-abx338429
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Integrin Alpha V (ITGAV) Antibody

20-abx325867
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Integrin alpha V Conjugated Antibody

C48926 100ul
EUR 397

Human Integrin alpha-V (ITGAV)

1-CSB-YP011877HU
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Integrin alpha-V(ITGAV),partial expressed in Yeast

Recombinant Integrin Alpha V (ITGaV)

4-RPB282Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Integrin Alpha V expressed in: E.coli

Recombinant Integrin Alpha V (ITGaV)

4-RPB282Mu01
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Integrin Alpha V expressed in: E.coli

Integrin alpha V Blocking Peptide

AF5152-BP 1mg
EUR 195

Anti-Hu CD72 Alexa Fluor® 488

A4-310-T100 100 tests
EUR 269

Anti-Bov CD9 Alexa Fluor® 488

A4-354-C100 0.1 mg
EUR 269

Anti-Hu CD30 Alexa Fluor® 700

A7-455-T100 100 tests
EUR 269

Anti-Hu CD94 Alexa Fluor® 700

A7-727-T100 100 tests
EUR 269

Anti-Hu CD56 Alexa Fluor® 700

A7-789-T100 100 tests
EUR 269

Donkey anti Goat IgG (H + L) (Alexa Fluor 647)

43R-ID028AF 500 ug
EUR 430
Description: Donkey anti Goat IgG (H + L) secondary antibody (Alexa Fluor 647)

Donkey anti Chicken IgY (H + L) (Alexa Fluor 647)

43R-ID060AF 300 ug
EUR 425
Description: Donkey anti Chicken IgY (H + L) (Fab'2) (Alexa Fluor 647)

Anti-Integrin alpha 5/ITGA5 Antibody

PB9254 100ug/vial
EUR 294

Anti-Integrin alpha 5/ITGA5 Antibody

A01911 100ug/vial
EUR 334

Human CellExp? Integrin alpha V beta 8, Human recombinant

P1122-10
EUR 164

Human CellExp? Integrin alpha V beta 8, Human recombinant

P1122-50
EUR 615

Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

A1092-200
EUR 729

Integrin beta-5 Antibody

AF5327 200ul
EUR 304
Description: Integrin β5 Antibody detects endogenous levels of total Integrin β5.

Integrin beta-5 Antibody

AF0185 200ul
EUR 304
Description: Integrin beta-5 antibody detects endogenous levels of total Integrin beta-5.

Integrin beta- 5 Antibody

ABF0185 100 ug
EUR 438

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