Ogólnoustrojowe dostarczanie ukierunkowane nanoterapii odwraca tętniaki aorty brzusznej wywołane przez angiotensynę II u myszy
Choroba tętniaka aorty brzusznej (AAA) powoduje rozszerzenie aorty, co prowadzi do pęknięcia aorty i śmierci, jeśli nie jest wcześnie leczona. Jest to 14. najczęstsza przyczyna zgonów w Stanach Zjednoczonych i 10. najczęstsza przyczyna zgonów mężczyzn w wieku powyżej 55 lat, dotykająca tysiące pacjentów.
Pomimo rozpowszechnienia AAA, nie ma bezpiecznych i skutecznych farmakoterapii dla pacjentów. Uszkodzenie elastycznej blaszki ściany tętniaka jest stałą cechą AAA, co czyni go idealnym celem do dostarczania leków do miejsca tętniaka. W tym badaniu połączyliśmy nanocząstki z przeciwciałem elastyny, które celuje tylko w zdegradowaną elastynę, oszczędzając jednocześnie zdrową elastynę.
Po wywołaniu tętniaka przez 4-tygodniową infuzję angiotensyny II (Ang II), dwa dwutygodniowe dożylne wstrzyknięcia nanocząsteczek obłożonych pentagalloiloglukozą (PGG) sprzężonych z przeciwciałem elastyny dostarczyły lek do miejsca tętniaka. Pokazujemy, że ukierunkowane dostarczenie PGG może odwrócić rozszerzenie aorty, złagodzić stan zapalny, przywrócić elastyczną blaszkę i poprawić właściwości mechaniczne aorty w miejscu AAA. Dlatego prosta terapia dożylna nanocząsteczek obciążonych PGG może być skuteczną opcją leczenia tętniaków we wczesnym i średnim stadium w celu odwrócenia progresji choroby i przywrócenia aorty do normalnej homeostazy.
Błąd połączenia.
Glikoinżynieria przeciwciało i przygotowanie koniugatu homogenicznego przeciwciało-lek
Koniugaty przeciwciało- lek (ADC) to klasa biofarmaceutyków, w których środki cytotoksyczne są sprzężone z przeciwciałami monoklonalnymi (mAb), umożliwiając ukierunkowane dostarczanie leków. Obecne ADC heterogeniczne ( sprzężone w losowych pozycjach zmiennych), cierpiała od kwestii stabilności, powtarzalności, skuteczność, itp Ostatnie postępy doprowadziły do opracowania preparatów jednorodnych ADC przez miejscowo specyficzną koniugacji, co pozwala na sterowanie lek To- przeciwciała stosunek . Podejścia te zwiększyły okno terapeutyczne, skuteczność i powtarzalność serii preparatów ADC. Przeciwciała niosą parę heterogennych N-glikanów w regionach Fc, które są krytyczne dla przeciwciała funkcjonować.
Koniugację leków za pomocą glikoinżynierii osiągnięto różnymi podejściami, w tym z użyciem endo-β-N-acetyloglukozaminidazy (ENGazy) i mutantów transferazy monosacharylowej. W tym artykule podsumowujemy różne podejścia inżynierii glikemicznej do koniugacji przeciwciało -lek i omawiamy ich zalety w opracowywaniu homogenicznych ADC nowej generacji.
psmhs
Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody
Description: Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. It is a member of the beta 3 integrin subfamily(cytoadhesins). The human locus for the av gene(VNRA) was previously mapped to the long arm of chromosome 2. Sims et al.(2000) localized the VNRA gene to 2q31. The gene contains 30 exons and spans over 93 kb of genomic DNA. It functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]
Rabbit Anti-Rat IgG (H+L)-Alexa 594 Fluor conjugate (adsorbed with human IgG)
Description: A Monoclonal antibody against Human ITGAV/Integrin Alpha V/CD51. The antibodies are raised in Mouse. This antibody is applicable in IHC-P, IF, IP, IHC-Fr, Flo, Func
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ITGAV/Integrin Alpha V/CD51 . This antibody is tested and proven to work in the following applications:
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha V (ITGaV) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha V (ITGaV) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Alpha V (ITGaV) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: Integrin alpha-5 belongs to the Integrin alpha chain family and contains 7 FG-GAP repeats. Integrin alpha-5 joins with Integrin- beta 1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin alpha-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion, ITGA5 participates in cell-surface mediated signalling.
Description: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
Integrin alpha V Antibody / ITGAV / Vitronectin Receptor
Description: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
Integrin alpha V Antibody / ITGAV / Vitronectin Receptor
Description: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
Description: A sandwich ELISA kit for detection of Integrin Alpha V from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin.
Description: This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Integrin alpha-5 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Integrin alpha-5 in samples from serum, plasma, tissue homogenates and other biological fluids.
Azotogenaza w Frankia z guzków korzeni Alnus incana (L.) Moench: immunolokalizacja białek Fe i MoFe podczas różnicowania pęcherzyków
Lokalizację azotazy badano w guzkach korzeni Alnus incana (L.) Moench w symbiozie z lokalnym źródłem Frankia. Guzki utrwalono w glutaraldehydzie i zatopiono w Epon lub LR White. Ultracienkie skrawki badano za pomocą TEM po inkubacji z surowicami odpornościowymi przeciwko azotazie i przeciwciałom wtórnym sprzężonym ze złotem . Zastosowano surowice odpornościowe przeciwko reduktazie dinitrogenazy (białko Fe) z Rhodospirillum rubrum i dinitrogenazę (białko MoFe) z Azotobacter vinelandii. Gęstość znacznika Immunogold w strzępkach i zarodnikach Frankii była niska i podobna do gęstości tkanki roślinnej.
Bardzo młode pęcherzyki bez przegród wykazywały gęstość znacznika białka Fe podobną do gęstości strzępek, podczas gdy młode pęcherzyki z kilkoma, zwykle nieprzekształcającymi się przegrodami, miały znaczną, ale wciąż niską gęstość znacznika. Dojrzałe pęcherzyki, silnie kompartmentalizowane z powodu przegród poprzecznych , zawierały statystycznie istotnie więcej znacznika białka Fe niż wszystkie inne typy komórek. Stare, degenerujące się pęcherzyki zawsze zawierały azotazę, około połowę mniej niż pęcherzyki dojrzałe, ale często więcej niż pęcherzyki młode. Podobnie, znacznik MoFe nie został wykryty w strzępkach, pojawił się u młodych, ale był największy w dojrzałych pęcherzykach. Widać, że różnicowanie pęcherzyków osiąga pewien etap rozwoju przed rozpoczęciem syntezy azotazy.
Optyczna spektroskopia emisyjna w plazmie sprzężonej indukcyjnie jako narzędzie oceny testów bocznego
Testy przepływu bocznego (LFA) to immunochromatograficzne urządzenia w miejscu opieki, które mają duży wpływ na diagnostykę choroby dzięki szybkiemu, niedrogiem i łatwemu w użyciu współczynnikowi kształtu. Chociaż LFA odniosły sukces jako narzędzia do rozmieszczania w terenie, mają stosunkowo niski restrict wykrywalności w porównaniu z bardziej złożonymi metodami. Co więcej, większość optymalizacji projektowania i produkcji jest osiągana poprzez czasochłonną i zasobochłonną optymalizację siłową. Pomimo zwiększonego zainteresowania produkcją LFA, potrzebne są bardziej ilościowe narzędzia do badania obecnych protokołów produkcyjnych, a tym samym do dalszej optymalizacji i usprawnienia rozwoju tych urządzeń.
W tej pracy skupiamy się na krytycznym składniku LFA, złocie koloidalnym sprzężonym z przeciwciałem detekcyjnym , jednym z najczęściej stosowanych elementów reporterowych. W badaniu tym wykorzystano optyczną spektroskopię emisyjną ze sprzężeniem indukcyjnym (ICP-OES) w połączeniu z czytnikiem przepływu bocznego do ilościowej analizy dystrybucji złota koloidalnego na liniach testu odczytu i kontrolnych, a także resztkowego złota na wkładce koniugatu i innych przepływach przez regiony. Naszym celem jest bardziej rygorystyczne zrozumienie obecnych projektów LFA, a także ilościowe zrozumienie niedociągnięć charakterystyk operacyjnych w celu przyszłej poprawy. Według naszej wiedzy jest to pierwszy przypadek, kiedy ICP-OES został użyty do badania początkowej dystrybucji złota koloidalnego naniewykorzystany LFA i jego redystrybucja po wykonaniu testu. Używając trzech różnych marek dostępnych na rynku LFA przeciw malarii, zmierzono zawartość złota w każdej sekcji LFA przy różnych testowych stężeniach pasożyta.
Zgodnie z oczekiwaniami całkowita masa złota pozostała niezmieniona po zastosowaniu LFA; jednakże całkowita masa początkowego złota i jego redystrybucja różniły się między producentami. Co ważne, te komercyjne projekty LFA mają również pewne nieodłączne nieefektywności ; na przykład tylko 30% całkowitego złota zdeponowanego na LFA marki A wiąże się z liniami testowymi i kontrolnymi, czyli częściami testu zawierającymi sygnał, który można zinterpretować. Korzystając z informacji zebranych za pomocą tej metody, przyszłe urządzenia mogą być bardziej celowo projektowane, aby skupić się na poprawie wydajności wiązania, co skutkuje obniżeniem kosztów, poprawą granic wykrywalności oraz mniejszą zmiennością między testami i producentami.
Wpływ surowicy na elektrochemiczną detekcję testów biologicznych posiadających etykiety nanocząstek Ag
Zbadano wpływ surowicy na elektrochemiczną detekcję testów biologicznych posiadających znaczniki detekcji nanocząstek srebra (AgNP). Zbadano zarówno take a look at modelowy , jak i take a look at biologiczny kanapkowy specyficzny dla antygenu dla markera niewydolności serca NT-proBNP. W obu przypadkach znaczniki AgNP były sprzężone z przeciwciałem do wykrywania . Detekcję elektrochemiczną przeprowadzono metodą wymiany galwanicznej / anodowej woltamperometrii strippingowej, w której Au 3+ wymienia się ze znacznikami AgNP . Testy przeprowadzono przy użyciu papierowej platformy elektrodowej.
Testy biologiczne wystawiano na działanie różnych warunków surowicy przed i podczas wykrywania. W tym artykule opisano trzy ważne wyniki. Po pierwsze, testy specyficzne dla modelu i antygenu można było utworzyć w nierozcieńczonej surowicy bez wykrywalnych zakłóceń ze strony składników surowicy. Po drugie, aby osiągnąć maksymalny możliwy sygnał elektrochemiczny, najwyższy procent surowicy, który może pozostać w buforze testowym podczas wykrywania elektrochemicznego, wynosi 0,25%, gdy nie przeprowadza się płukania. Wyniki testu stają się niedokładne, gdy obecne jest 0,50% lub więcej surowicy . Po trzecie, czynniki hamujące wymianę galwaniczną w surowicy prawdopodobnie dotyczą powierzchniowej adsorpcji biomolekuł na znacznikach AgNP, chelatacji Au 3+ według składników surowicy lub obu. Przedstawione tutaj wyniki dostarczają ogólnych wskazówek dotyczących stosowania metalowych znaczników NP w testach elektrochemicznych w płynach biologicznych.
Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody
Description: Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. It is a member of the beta 3 integrin subfamily(cytoadhesins). The human locus for the av gene(VNRA) was previously mapped to the long arm of chromosome 2. Sims et al.(2000) localized the VNRA gene to 2q31. The gene contains 30 exons and spans over 93 kb of genomic DNA. It functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]
Rabbit Anti-Rat IgG (H+L)-Alexa 594 Fluor conjugate (adsorbed with human IgG)
Description: A Monoclonal antibody against Human ITGAV/Integrin Alpha V/CD51. The antibodies are raised in Mouse. This antibody is applicable in IHC-P, IF, IP, IHC-Fr, Flo, Func
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ITGAV/Integrin Alpha V/CD51 . This antibody is tested and proven to work in the following applications:
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha V (ITGaV) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha V (ITGaV) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha V (ITGaV) in tissue homogenates, cell lysates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Alpha V (ITGaV) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: Integrin alpha-5 belongs to the Integrin alpha chain family and contains 7 FG-GAP repeats. Integrin alpha-5 joins with Integrin- beta 1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin alpha-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion, ITGA5 participates in cell-surface mediated signalling.
