Wpływ terapii statynami na występowanie incydentów sercowo-naczyniowych, raka i śmiertelności z jakiejkolwiek przyczyny u osób żyjących z HIV : metaanaliza
Możliwy wpływ terapii statynami na ryzyko incydentów sercowo-naczyniowych, raka i śmiertelność z jakiejkolwiek przyczyny u osób żyjących z HIV (PLWH) pozostaje niejasny. Przeprowadziliśmy metaanalizę w celu systematycznej oceny skuteczności statyn w PLWH.
Odpowiednie badania kohortowe uzyskano poprzez przeszukiwanie baz danych Medline, Embase i Web of Science do 14 czerwca 2021 r. Dane połączono z modelem efektów losowych poprzez uwzględnienie heterogeniczności między badaniami.
Do metaanalizy kwalifikowało się łącznie 12 wielowymiarowych badań kohortowych, w których uczestniczyło 162 252 uczestników, a 36 253 (22,3%) z nich było użytkownikami statyn. Zbiorcze wyniki wykazały, że stosowanie statyn było niezależnie związane ze zmniejszonym ryzykiem śmiertelności u chorych na PLWH [skorygowany współczynnik ryzyka (RR): 0,56, 95% CI: 0,44 do 0,72, p < 0,001, I2 = 41%]. Ponadto wyniki metaanalizy wykazały, że stosowanie statyn nie było istotnie związane ze zmniejszonym ryzykiem incydentów sercowo-naczyniowych u PLWH w porównaniu z osobami niestosującymi statyn (RR: 1,14, 95% CI: 0,80 do 1,63, p = 0,48, 2 = 42%) . Jednak stosowanie statyn było istotnie związane ze zmniejszonym ryzykiem raka u PLWH (RR: 0,73, 95% CI: 0,58 do 0,93, p = 0,009, I2 = 49 %). Analizy wrażliwości poprzez wykluczenie jednego badania na raz wykazały spójne wyniki. Nie zaobserwowano znaczących stronniczości publikacji.

Stosowanie statyn wiąże się ze zmniejszoną śmiertelnością z jakiejkolwiek przyczyny w PLWH. Ponadto stosowanie statyn wiąże się ze zmniejszonym ryzykiem raka, chociaż ryzyko zdarzeń sercowo-naczyniowych wydaje się nie mieć istotnego wpływu.
Zmiany w mikrobiomie jamy ustnej w zakażeniu wirusem HIV : przyczyny , skutki i potencjalne interwencje
Przyczyny i wyniki przyjęcia i badania gruźlicy u dorosłych z zaawansowanym wirusem HIV w południowoafrykańskich szpitalach: dane z badania TB Fast Track Trial
WSC-2700 MyMiniSpin CE marked |
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4002700 | Atto | each | 45000 EUR |
HIV Type 1 p24 Antigen ELISA (96 Determinations) |
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0801111 | Zeptometrix | 96T | 621 EUR |
HIV Type 1 p24 Antigen ELISA (96 Determinations) |
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801111 | Zeptometrix | 96 Determinations | 591 EUR |
HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations) |
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801002 | Zeptometrix | 96 Determinations | 574 EUR |
HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations) |
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0801002 | Zeptometrix | 96T | 603 EUR |
HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations) |
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0801200 | Zeptometrix | 5 X 96T | 2563 EUR |
HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations) |
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801200 | Zeptometrix | 5 X 96 Determinations | 2330 EUR |
WSE-6370K LGIII lite Basic CE marked |
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2006375 | Atto | each | 20000 EUR |
WSC-2615 MyMiniBLOCK C&H CE marked |
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4002615 | Atto | each | 96800 EUR |
HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations) |
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801008 | Zeptometrix | 5 X 96 Determinations | 2386 EUR |
HIV Type 1 p24 Antigen ELISA 2.0 (5 X 96 Determinations) |
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0801008 | Zeptometrix | 5 X 96T | 2505 EUR |
HIV Type 1 p24 Extended Range Kit (5 x 96 Determinations) |
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0801137 | Zeptometrix | 5 x 96T | 87 EUR |
HIV Type 1 p24 Extended Range Kit (5 x 96 Determinations) |
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801137 | Zeptometrix | 5 x 96 Determinations | 83 EUR |
WSE-6370 LGIII lite with UV set CE marked |
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2006370 | Atto | each | 23000 EUR |
Alere™ hCG Easy Pregnancy |
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UPK009A | Abbott | 25T/Kit | 94.8 EUR |
Alere BinaxNOW Influenza A&B Card |
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173-416-000 | Abbott | 10 Tests/Kit | 276 EUR |
SOX-2/SRY (sex determining region Y)-box 2 |
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MO47038 | Neuromics | 100 ul | 418.8 EUR |
SRY (sex determining region Y)-box 2 TAT Protein |
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20-abx261008 | Abbexa |
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Sex Determining Region Y-Box 2 (SOX2) Antibody |
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abx433503-200ul | Abbexa | 200 ul | 543.6 EUR |
Left-Right Determination Factor 2 Protein |
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20-abx263210 | Abbexa |
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Sry (Sex Determining Region Y)-Box 2 (SOX2) Antibody |
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20-abx115822 | Abbexa |
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Brand Marked Capillary White 1-5ul Pipette |
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PIP3000 | Scientific Laboratory Supplies | PK250 | 73.2 EUR |
Dog Sex Determining Region Y Box Protein 2 ELISA kit |
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E08S0148-192T | BlueGene | 192 tests | 1524 EUR |
Dog Sex Determining Region Y Box Protein 2 ELISA kit |
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E08S0148-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Dog Sex Determining Region Y Box Protein 2 ELISA kit |
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E08S0148-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Rat Sex Determining Region Y Box Protein 2 ELISA kit |
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E02S0148-192T | BlueGene | 192 tests | 1524 EUR |
Rat Sex Determining Region Y Box Protein 2 ELISA kit |
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E02S0148-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Rat Sex Determining Region Y Box Protein 2 ELISA kit |
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E02S0148-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Pig Sex Determining Region Y Box Protein 2 ELISA kit |
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E07S0148-192T | BlueGene | 192 tests | 1524 EUR |
Pig Sex Determining Region Y Box Protein 2 ELISA kit |
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E07S0148-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Pig Sex Determining Region Y Box Protein 2 ELISA kit |
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E07S0148-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Goat Sex Determining Region Y Box Protein 2 ELISA kit |
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E06S0148-192T | BlueGene | 192 tests | 1524 EUR |
Goat Sex Determining Region Y Box Protein 2 ELISA kit |
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E06S0148-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Goat Sex Determining Region Y Box Protein 2 ELISA kit |
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E06S0148-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Protein |
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20-abx260592 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx135790 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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abx234746-100ug | Abbexa | 100 ug | 577.2 EUR |
Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx103721 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx103722 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx103723 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx177319 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx213103 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx213149 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx321803 | Abbexa |
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Left/Right Determination Factor 2 (LEFTY2) Antibody |
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20-abx113456 | Abbexa |
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Left-Right Determination Factor 1 Protein |
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20-abx263218 | Abbexa |
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Dog Left/Right Determination Factor 1 ELISA kit |
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E08L0343-192T | BlueGene | 192 tests | 1524 EUR |
Dog Left/Right Determination Factor 1 ELISA kit |
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E08L0343-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Dog Left/Right Determination Factor 1 ELISA kit |
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E08L0343-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Rat Left/Right Determination Factor 1 ELISA kit |
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E02L0343-192T | BlueGene | 192 tests | 1524 EUR |
Rat Left/Right Determination Factor 1 ELISA kit |
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E02L0343-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Rat Left/Right Determination Factor 1 ELISA kit |
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E02L0343-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Pig Left/Right Determination Factor 1 ELISA kit |
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E07L0343-192T | BlueGene | 192 tests | 1524 EUR |
Pig Left/Right Determination Factor 1 ELISA kit |
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E07L0343-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Pig Left/Right Determination Factor 1 ELISA kit |
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E07L0343-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Rat Sex Determining Region Y Box Protein 2 (SOX2) CLIA Kit |
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20-abx491459 | Abbexa |
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Mouse Sex Determining Region Y Box Protein 2 ELISA kit |
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E03S0148-192T | BlueGene | 192 tests | 1524 EUR |
Mouse Sex Determining Region Y Box Protein 2 ELISA kit |
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E03S0148-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Mouse Sex Determining Region Y Box Protein 2 ELISA kit |
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E03S0148-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Human Sex Determining Region Y Box Protein 2 ELISA kit |
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E01S0148-192T | BlueGene | 192 tests | 1524 EUR |
Human Sex Determining Region Y Box Protein 2 ELISA kit |
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E01S0148-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Human Sex Determining Region Y Box Protein 2 ELISA kit |
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E01S0148-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx238125-100ug | Abbexa | 100 ug | 577.2 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx238126-100ug | Abbexa | 100 ug | 577.2 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx104948 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx174534 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx178385 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx212668 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx211709 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx331447-100ul | Abbexa | 100 ul | 510 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx031506-400ul | Abbexa | 400 ul | 627.6 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx031506-80l | Abbexa | 80 µl | 343.2 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx025415-400ul | Abbexa | 400 ul | 627.6 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx025415-80l | Abbexa | 80 µl | 343.2 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx025416-100ul | Abbexa | 100 ul | 627.6 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx015998-100ul | Abbexa | 100 ul | 493.2 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx018372-100ul | Abbexa | 100 ul | 460.8 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx018374-100ul | Abbexa | 100 ul | 460.8 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx019164-100ug | Abbexa | 100 ug | 410.4 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx127117-50ul | Abbexa | 50 ul | 493.2 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx126622 | Abbexa |
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Recombinant Human SRY (sex determining region Y)-box 2 |
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7-06487 | CHI Scientific | 5µg | Ask for price |
Recombinant Human SRY (sex determining region Y)-box 2 |
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7-06488 | CHI Scientific | 25µg | Ask for price |
Recombinant Human SRY (sex determining region Y)-box 2 |
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7-06489 | CHI Scientific | 1mg | Ask for price |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx000763 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx004718 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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abx011547-100ul | Abbexa | 100 ul | 493.2 EUR |
Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx159698 | Abbexa |
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Sex Determining Region Y Box Protein 2 (SOX2) Antibody |
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20-abx142239 | Abbexa |
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Goat Left/Right Determination Factor 1 ELISA kit |
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E06L0343-192T | BlueGene | 192 tests | 1524 EUR |
Goat Left/Right Determination Factor 1 ELISA kit |
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E06L0343-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Goat Left/Right Determination Factor 1 ELISA kit |
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E06L0343-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Rat Left/Right Determination Factor 2 (LEFTY2) Protein |
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20-abx067738 | Abbexa |
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Rat Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit |
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abx256017-96tests | Abbexa | 96 tests | 801.6 EUR |
Pig Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit |
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abx360812-96tests | Abbexa | 96 tests | 990 EUR |
Rat Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit |
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DLR-SOX2-Ra-48T | DL Develop | 48T | 609.6 EUR |
Rat Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit |
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DLR-SOX2-Ra-96T | DL Develop | 96T | 793.2 EUR |
Rat Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit |
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20-abx156110 | Abbexa |
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Rat SOX2(Sex Determining Region Y Box Protein 2) ELISA Kit |
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ER1349 | FN Test | 96T | 628.92 EUR |
Rat Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit |
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RDR-SOX2-Ra-48Tests | Reddot Biotech | 48 Tests | 640.8 EUR |